Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
Certification Provider: MRCPUK
Corresponding Certification: MRCPUK Certification
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- Total Questions: 200
- Updated on: Nov 08, 2026
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- Total Questions: 200
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- Total Questions: 200
- Updated on: Nov 08, 2026
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A tight study schedule does not have to slow your SEND preparation. Actual4dump brings 200 focused practice questions for MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) into one printable, online, or desktop workflow, so you can use short study windows more efficiently in 2026.
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MRCPUK SEND Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Reproductive and Other Endocrine Conditions | 15% | - Disorders of puberty and sex development - Obesity and lipid disorders - Endocrine hypertension and rare syndromes - Polycystic ovary syndrome |
| Diabetes Mellitus | 40% | - Type 2 Diabetes
|
| Thyroid Disorders | 15% | - Thyroid nodules and cancer - Hypothyroidism and myxoedema coma - Thyroiditis and subclinical dysfunction - Hyperthyroidism: Graves’ disease, toxic nodular disease |
| Pituitary and Hypothalamic Disorders | 15% | - Diabetes insipidus and SIADH - Hypopituitarism and hormone replacement - Pituitary adenomas: prolactinoma, acromegaly, Cushing's disease - Hypothalamic dysfunction |
| Adrenal and Parathyroid/Metabolic Bone Disorders | 15% | - Hyperparathyroidism, hypoparathyroidism - Primary/secondary hyperaldosteronism - Cushing's syndrome, Addison's disease, phaeochromocytoma - Osteoporosis, osteomalacia, Paget's disease |
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination): Frequently Asked Questions
The SEND exam leads to the Specialty Certificate in Endocrinology and Diabetes certification from MRCP(UK) / Federation of the Royal Colleges of Physicians of the UK. It is positioned at the Specialist / Advanced level. The exam validates the knowledge and skills expected of candidates preparing for MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination).
Related certifications include:
- MRCP(UK)
- CCT (Certificate of Completion of Training)
- CESR
The SEND exam includes 200 (100 per paper) questions and allows 360 (180 minutes per paper, 1-hour break). Before test day, divide the available time by the number of questions in a timed practice set to establish a steady per-question pace. If a difficult item starts consuming too much time, mark it for review and move forward instead of losing momentum. A full timed practice session can help you decide when to move on, when to return, and how much buffer to reserve for a final check.
The passing score for SEND is Variable scaled score (Angoff standard-setting, published post-exam), and the official exam fee is £585 (UK), £755 (International) - 2025/26 rates. Because a retake requires paying the exam fee again, use timed practice results as a readiness check before scheduling your next attempt. If your performance remains inconsistent, continue reviewing weak domains and repeat a timed session before booking the exam.
No formal prerequisite; MRCP(UK) recommended; mandatory for CCT in Endocrinology & Diabetes
Eligibility rules can change, so confirm the current requirements on the official exam page before registering.
You can register through the official channels listed below:
The available exam delivery method is Computer-based at global Pearson VUE test centres; no online proctoring.
The official training options include:
After reviewing the recommended training, reinforce what you learned with Actual4dump's 200 practice questions for SEND.
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If you purchase the corresponding SEND preparation material and do not pass that exam within 60 days of purchase, you may apply for a full refund under the 100% Money Back Guarantee. The request requires a scanned exam enrollment slip and the official Score Report PDF, submitted within two days after the exam. Eligible requests are processed within seven days.
Claims are not eligible if the exam was taken within three days of purchase, the product was downloaded without an exam attempt, the order was free or expired, or the candidate name does not match the payer name. If you prefer an exchange instead of a refund, you can receive two free products of equal value while keeping the update service for your original purchase.
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The current SEND outline is organized into 5 top-level domains. The first listed areas include:
- Diabetes Mellitus (40%)
- Pituitary and Hypothalamic Disorders (15%)
- Adrenal and Parathyroid/Metabolic Bone Disorders (15%)
Review the Exam Topics section above for the complete outline and any nested subtopics.
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
A 25-year-old woman presented with a solitary nodule in the right lobe of her thyroid gland.
Investigations:
serum thyroid-stimulating hormone0.45 mU/L (0.4-5.0)
serum free T420.7 pmol/L (10.0-22.0)
The presence of which feature would most increase the likelihood of malignancy?
- A. elevated serum thyroglobulin concentration
- B. high titre of thyroid peroxidase antibodies
- C. microcalcification seen within the nodule on ultrasound scan
- D. size of nodule >1.0 cm in maximum diameter
- E. increased peripheral vascularity of nodule on Doppler ultrasound
Correct Answer: C 🗳️
A 41-year-old man presented to his general practitioner with symptoms of palpitations, sweating and anxiety. His blood pressure was 160/102 mmHg. He was advised to take propranolol 40 mg twice daily but was admitted to hospital later that week with an episode of pulmonary oedema.
On examination at the time of admission, he was noted to be pale and sweating and he had a blood pressure of 210/124 mmHg. A phaeochromocytoma was suspected.
What is the most likely cause of the cardiovascular deterioration following administration of propranolol?
- A. ?1-adrenoceptor blockade leading to acute left ventricular dysfunction
- B. propranolol acting as an agonist at ?1-adrenoceptors
- C. inhibition of catechol-O-methyltransferase by propranolol leading to an increase in circulating noradrenaline
- D. loss of ?2-adrenoceptor-mediated vasodilatation
- E. inadequate ?-adrenoceptor blockade because of the short half-life of the drug
Correct Answer: D 🗳️
A 63-year-old woman with diet-controlled type 2 diabetes mellitus was admitted with biventricular cardiac failure. She had a history of myocardial infarction 3 years previously. She was taking aspirin 75 mg daily, simvastatin 20 mg daily, furosemide 40 mg daily and ramipril 10 mg daily. She responded well to increased diuretic therapy.
Urinalysis showed glucose 1+.
Investigations:
haemoglobin112 g/L (115-165)
serum sodium135 mmol/L (137-144)
serum potassium4.7 mmol/L (3.5-4.9)
serum creatinine162 umol/L (60-110)
estimated glomerular filtration rate28 mL/min/1.73 m2 (>60)
serum troponin T<0.01 ug/L (<0.01)
haemoglobin A1c66 mmol/mol (20-42)
What is the most appropriate treatment for her diabetes after discharge?
- A. gliclazide
- B. linagliptin
- C. subcutaneous insulin
- D. exenatide
- E. dapagliflozin
Correct Answer: A 🗳️
A 48-year-old woman presented with a 2-year history of weight gain, easy bruising and
mood disturbance.
Investigations:
fasting plasma glucose6.9 mmol/L (3.0-6.0)
low-dose dexamethasone suppression test (2 mg/day for 48 h):
serum cortisol200 nmol/L (<50)
24-h urinary free cortisol (?3)670, 400 and 300 nmol (55-250)
plasma adrenocorticotropic hormone (09.00 h)25.0 pmol/L (3.3-15.4)
MR scan of pituitarynormal
What test is most likely to give a definitive diagnosis?
- A. CT scan of chest
- B. octreotide scan
- C. corticotropin-releasing hormone test
- D. high-dose dexamethasone suppression text (8 mg/day for 48 h)
- E. petrosal sinus sampling
Correct Answer: E 🗳️
A 77-year-old woman presented with a 10-week history of facial hirsutism, scalp hair loss and deepening of the voice.
On examination, her body mass index was 32 kg/m2 (18-25). Her blood pressure was 164/94 mmHg. She had coarse terminal hairs on her upper lip and beard areas. Abdominal examination was normal, but she refused examination of her external genitalia.
Investigations:
serum sodium144 mmol/L (137-144) serum potassium3.6 mmol/L (3.5-4.9) serum urea7.7 mmol/L (2.5-7.0) serum creatinine122 umol/L (60-110) fasting plasma glucose6.4 mmol/L (3.0-6.0) serum testosterone17.2 nmol/L (0.5-3.0) serum luteinising hormone2.2 U/L (>30.0)
What is the most appropriate initial investigation?
- A. serum oestradiol
- B. serum dehydroepiandrosterone sulphate
- C. plasma adrenocorticotropic hormone and serum cortisol
- D. CT scan of abdomen and pelvis
- E. overnight dexamethasone suppression test (after 1 mg dexamethasone)
Correct Answer: D 🗳️
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